Blogs » Law and Legal Services » Deutshmann Personal Injury & Disability Law - PERSONAL INJURY & DISABILITY LAW


Deutshmann Personal Injury & Disability Law - PERSONAL INJURY & DISABILITY LAW
“Hacking” the Immune System May Prevent Long Term Disability After Brain Injury
Return to Blog 

A recent publication in Science “Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury” examined the secondary injuries following traumatic brain injury. They investigated why there is a continued decline in function of the brain following the injury and what it is that causes this. 

What is TBI and Why Does it Matter?

TBI (traumatic brain injury) is a leading cause of disability in children and adults worldwide and has many causes from car accidents, sporting accidents, violent assaults and slip and falls. The costs – human, financial, social, and healthcare – are enormous and life-altering.

What Does Research Find?

A new study examined the effects of TBI on the thalamus region of the brain which regulates sleep and attention. It found that the thalamus is more damaged months after injury than the cortex of the brain. The researchers speculate that this occurs due to increased levels of a molecule called Clq that triggers the part of the immune system called the Classical Complement Pathway. This mechanism plays a key role in clearing dead cells and pathogens and in controlling the inflammatory immune response.

What is the Purpose of Clq Molecule?

Clq can have two impacts on the brain:

  • Accumulation of it can cause abnormal elimination of synapses and contribute to neurodegenerative disease
  • It is also required in proper amounts for normal brain development, and it protects the central nervous system from infection.

In the event of TBI the researchers found that the Clq molecule lingered in the thalamus for months after the initial injury at abnormally high levels. This accumulation was associated with:

  • Inflammation
  • Neuronal death
  • Brain circuits behave dysfunctionally

Why is Too Much Clq Bad?

The accumulation could be the underlying cause of many of the long term symptoms of TBI including

  • Brain injury
  • Sleep disruption
  • Epilepsy

These symptoms then contribute to other issues including mood disorders, depression and mental health decline.

The researchers conducted their research on mice that they had genetically engineered to lack the Clq molecules. The impact of brain injury on these modified mice appeared much worse than in the control group suggesting that Clq is critical at the time of injury to prevent cell death.

Why this is important

Since TBI affects almost 70 million people a year worldwide we need to develop therapies that prevent the long-term damage to the brain following TBI. This would save lives, save money, and allow those with TBI to live longer healthier and more productive lives.

What Should You Do if You or A Loved One Sustain TBI?

If you or a loved one have been injured and suffered a TBI as a result of someone else’s negligence you should contact one of our experienced personal injury lawyers At Deutschmann Personal Injury and Disability Law immediately. We offer a free initial consultation and will work for you to achieve the best outcome for you and your family. Don’t face your situation alone. Call us today 1 (866) 414-4878

Posted on Monday, Feb 28, 2022 - 07:27:00 AM EST
 Comments  (0) Post a Comment 
   By Deutschmann Personal Injury & Disability Law - Visit Our Business Directory Listing  |   Return to Blog 

Blogs Home   |   Start a Blog   |   Subscribe To Blog
News   |   Announcements   |   Events Calendar
Contact The News Editor   |   News FAQs

    <<     November  2022     
S M Tu W Th F S
    1 2 3 4 5
6 7 8 9 10 11 12
13 14 15 16 17 18 19
20 21 22 23 24 25 26
27 28 29 30      
Jump to:

Article Categories
Car Insurance
Disability Law
Law Enforcement
Personal Injury Law

Recent Articles
Smartwatches are a bigger distraction than phones now
Old Grey Mayors Episode 33 - Revisiting the 1989’s Elmira Uniroyal Aquifer Contamination with Gerry
We're Proud Supporters of Public Art in the Region
One Quarter of Children with Mild Traumatic Brain Injury Suffer Post-Concussion Symptoms
Episode 30: Bob Williams
Self Driving Cars Tackling Complex Roads in Canada
Bike Lanes and Pedestrians Don’t Mix
Playground Safety
Has Long Covid Prompted Research On Other Chronic Illness?
How Do Brain Injury and Personality Change Go Hand in Hand?
America Enacts Safety Standards for Autonomous Vehicles and Automated Vehicles
Brain Injury Can Result in Depression
Automaker Ford will use autnomous vehicles to deliver groceries to seniors in need
“Hacking” the Immune System May Prevent Long Term Disability After Brain Injury
New Research Finds that Concussion Monitoring Could Occur using Urine Samples
Vision Zero’s commitment to continuously and preemptively improve safety on the roads
City of Kitchener Continues to Implement Vision Zero
High Purity Prescription CBD Oil May Be An Effective COVID Therapy
Long COVID or Post-Acute Sequelae SARS-CoV-2 (PASC) – What is it?
Long COVID and Disability Benefits

Articles by Month of Posting
May 2022
March 2022
February 2022
December 2021
November 2021
October 2021
September 2021
August 2021
July 2021
June 2021
May 2021
April 2021
March 2021
February 2021
January 2018
January 2017
January 2016
August 2015
July 2015
June 2015
May 2015
April 2015
March 2015
February 2015
January 2015
December 2014
November 2014
October 2014
September 2014
August 2014
July 2014
June 2014
May 2014
April 2014
March 2014
February 2014
January 2014
December 2013
November 2013
October 2013
September 2013
August 2013
July 2013
June 2013
May 2013
April 2013
March 2013
February 2013
January 2013
December 2012
August 2012
July 2012
May 2012
April 2012
March 2012
January 2008
July 2007
May 2007
April 2007